Ritalin May Cause Changes In The Brain’s Reward Areas
Posted Feb 10 2009 10:06am
A common treatment for attention deficit/hyperactivity disorder, prescribed millions of times a year, may change the brain in the same ways that cocaine does, a new study in mice suggests. Research from Rockefeller University shows that methylphenidate, commonly known as Ritalin, causes physical changes in neurons in reward regions of mouse brains. In some cases, the effects overlapped with those of cocaine.
The study highlights the need for more research into methylphenidate’s long-term effects on the brain, the researchers say. The findings were published February 3 in the Proceedings of the National Academy of Sciences.
The researchers, led by Yong Kim, senior research associate, and Paul Greengard, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience, exposed mice to two weeks of daily injections of cocaine or methylphenidate. They then examined reward areas of the brain for changes in dendritic spine formation — related to the formation of synapses and the communication between nerve cells — and the expression of a protein called delta Fos B, which has been implicated in the long-term actions of addictive drugs.