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Regenerative Capacity of Heart Tissue Explored

Posted Jan 04 2013 10:11pm
Posted on Jan. 2, 2013, 6:01 a.m. in Regenerative Medicine Cardio-Vascular

University of Texas Southwestern Medical Center (Texas, USA) researchers have pinpointed a molecular mechanism needed to unleash the heart's ability to regenerate, a critical step toward developing eventual therapies for damage suffered following a heart attack.  In a mouse model, Hesham Sadek and colleagues found that microRNAs – tiny strands that regulate gene expression – contribute to the heart's ability to regenerate.   The hearts of young rodents mounted a robust regenerative response following myocardial infarction, but this restorative activity only occurs during the first week of life. The team  then discovered that a microRNA called miR-15 disables the regenerative capacity after one week, but when miR-15 is blocked, the regenerative process can be sustained much longer.  By determining the fundamental mechanisms that control the heart's natural regenerative on-off switch, researchers have begun to better understand the No. 1 hurdle in cardiovascular research – the inability of the heart to regenerate following injury.  The study authors conclude that: “the neonatal mammalian heart can regenerate after myocardial infarction through proliferation of preexisting cardiomyocytes and that the miR-15 family contributes to postnatal loss of cardiac regenerative capacity.”

Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D,  Sadek HA, et al.  “Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.” Proc Natl Acad Sci U S A. 2012 Dec 17.

World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies Showcases Innovations in Clinical Aging Intervention:
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The rate of people who seek preventive cancer screenings has fallen over the last ten years in the United States.
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High perceived stress associates with a moderately increased risk of incident coronary heart disease
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People may lose 30 minutes of life expectancy for every two cigarettes, for being 11 pounds overweight, and for eating an extra portion of red meat daily.
Supplementation with omega-3 fatty acids may postpone the onset of metabolic disorders and associated declines in cognitive functions.
Boston University (US) team develops technique to generate human induced pluripotent stem cells (iPSC) from stem cells in the peripheral blood.
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Johns Hopkins University (US) team develops a new hydrogel compound that functions as an artificial skin dressing.
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US team has engineered adult stem cells that scientists can grow continuously in culture, potentially expediting regenerative medical applications.
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US team has induced robust regeneration of nerve connections that control voluntary movement after spinal cord injury.
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Anti-Aging Forum MLDP Join A4M
#101 - Flush with Food
Thanks to today’s contemporary lifestyle of fast foods, our 24/7/365 accessibility, and the growing pressures of many of us in our professional and personal lives, we have become a population of toxemics. “Toxemia” is the medical term that defines a condition in which our bodies accumulate poisonous substances to such a point that levels exceed the ability of our body systems to cleanse them away. Medical conditions associated with toxemia include:

• Hepatitis A, B, C, D, E, F, and G

• Liver damage, including cirrhosis

• Diarrhea

• Constipation

• Irritable bowel syndrome

• Leaky gut syndrome

Include fiber in your everyday diet, because fiber can promote the digestive and elimination processes to help your body get rid of toxins (see Tip 42).
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