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Regenerative Capacity of Heart Tissue Explored

Posted Jan 04 2013 10:11pm
Posted on Jan. 2, 2013, 6:01 a.m. in Regenerative Medicine Cardio-Vascular

University of Texas Southwestern Medical Center (Texas, USA) researchers have pinpointed a molecular mechanism needed to unleash the heart's ability to regenerate, a critical step toward developing eventual therapies for damage suffered following a heart attack.  In a mouse model, Hesham Sadek and colleagues found that microRNAs – tiny strands that regulate gene expression – contribute to the heart's ability to regenerate.   The hearts of young rodents mounted a robust regenerative response following myocardial infarction, but this restorative activity only occurs during the first week of life. The team  then discovered that a microRNA called miR-15 disables the regenerative capacity after one week, but when miR-15 is blocked, the regenerative process can be sustained much longer.  By determining the fundamental mechanisms that control the heart's natural regenerative on-off switch, researchers have begun to better understand the No. 1 hurdle in cardiovascular research – the inability of the heart to regenerate following injury.  The study authors conclude that: “the neonatal mammalian heart can regenerate after myocardial infarction through proliferation of preexisting cardiomyocytes and that the miR-15 family contributes to postnatal loss of cardiac regenerative capacity.”

Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D,  Sadek HA, et al.  “Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.” Proc Natl Acad Sci U S A. 2012 Dec 17.

  
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Anti-Aging Forum MLDP Join A4M
#101 - Flush with Food
Thanks to today’s contemporary lifestyle of fast foods, our 24/7/365 accessibility, and the growing pressures of many of us in our professional and personal lives, we have become a population of toxemics. “Toxemia” is the medical term that defines a condition in which our bodies accumulate poisonous substances to such a point that levels exceed the ability of our body systems to cleanse them away. Medical conditions associated with toxemia include:

• Hepatitis A, B, C, D, E, F, and G

• Liver damage, including cirrhosis

• Diarrhea

• Constipation

• Irritable bowel syndrome

• Leaky gut syndrome

Include fiber in your everyday diet, because fiber can promote the digestive and elimination processes to help your body get rid of toxins (see Tip 42).
 
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