Recombinant DNA Clone Containing a Genomic Fragment of PfHRP-II Gene from Plasmodium falciparum

Description of Invention:
A fragment of the PfHRP-II gene of Plasmodium falciparum was cloned using recombinant DNA techniques. This clone is capable of encoding PfHRP-II protein, a water-soluble, histidine-rich molecule that may be effective in the detection, diagnosis, and treatment of human malaria, which is caused by the parasite, P. falciparum. This protein may be particularly useful in the development of an anti-malaria vaccine. To date, no malaria vaccine has been successful in human trials and most exhibit only limited effectiveness in primates.

Inventors:
Thomas E Wellems (NIAID)


Patent Status:
HHS, Reference No. E-318-1986/0
US, , Patent No. 5,296,382, Issued 22 Mar 1994
US, , Patent No. 5,476,785, Issued 19 Dec 1995
HHS, Reference No. E-318-1986/0



Portfolios:
Infectious Diseases
Infectious Diseases - Vaccines



For Licensing Information Please Contact:
Cristina Thalhammer-Reyero Ph.D., M.B.A.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 33,
Rockville, MD 20852
United States
Email: thalhamc@mail.nih.gov
Phone: 301-435-4507
Fax: 301-402-0220


Ref No: 1191

Updated: 02/2011