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Real-Time PCR for Detecting Legionella Species and Discriminating Legionella pneumophila

Posted Aug 12 2013 8:00pm

Description of Invention:
Legionella pneumophila is the causative species in most cases of Legionnaires' disease (LD). CDC scientists have developed a real-time PCR assay capable of detecting all Legionella species and discriminating L. pneumophila from other Legionella species. LD is typically difficult to diagnose from a clinical standpoint as it confers no unique clinical features or symptoms. This assay provides a rapid and accurate alternative to laborious PCR assays, prone to aberrant results. It provides a sensitive alternative for diagnosis of Legionnaires' disease and detection of L. pneumophila.

Applications:
  • Diagnostic for Legionnaires’ disease
  • Detection of all Legionella species and specific discrimination of L. pneumophila


Advantages:
  • Faster than immunoassays
  • Less laborious than current LD diagnostics
  • Rapid, sensitive, and specific
  • Curtails misdiagnoses associated with serological evaluations
  • Easily adaptable to kit form


Development Status:
  • Early-stage
  • In vitro data available


Inventors:
Robert F Benson (CDC)
Brian F Holloway (CDC)
Karen A McCaustland (CDC)
Patrick G Yant (CDC)


Patent Status:
HHS, Reference No. E-194-2013/0
PCT, Application No. PCT/US2009/068461 filed 17 Dec 2009
US, Application No. 13/140,922 filed 20 Jun 2011


Relevant Publication:
  1. Yang G, et al. [ PMID 19438641 ]



For Licensing Information Please Contact:
Whitney Blair
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: blairw2@mail.nih.gov
Phone: 301-435-4937
Fax: 301-402-0220


Ref No: 2613

Updated: 08/2013

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