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Quantitative Real-Time RT-PCR Array for Detection of Human Herpesvirus 6A Gene Expression

Posted Feb 16 2009 4:00pm

Description of Invention:
This invention describes an RT-PCR array that allows for the simultaneous transcriptional profiling of the human herpesvirus HHV6A genome. It may be used to determine the contribution of HHV6A to the development of lymphomas, other types of cancer or diseases where an infectious agent is suspected. Primer pairs are designed to amplify under identical reaction conditions and are rigorously tested to ensure specificity for the HHV6A ORFs to the exclusion of all other human herpesviruses including HHV6B and HHV7.

Recent findings of the association of active viral genes with cancer cells have led to new proposed targets for cancer vaccines and therapeutics. The ability to distinguish HHV6A from other related herpesviruses, and to independently assay viral gene activity, may lead to the identification of new viral targets for the treatment of cancers and other diseases where HHV6A transcription is active.

Applications:
  • Analysis of whole HHV6A genome expression
  • Identification of HHV6A gene expression and its association with disease states


Development Status:
Late stage

Inventors:
Rachel K Bagni (NCI)
Francis W Ruscetti (NCI)


Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The National Cancer Institute, Advanced Technology Program, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize virus specific quantitative real-time RT-PCR arrays. Please contact John D. Hewes, Ph.D. at 301-435-3121 or hewesj@mail.nih.gov for more information.


Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Diagnostics
Infectious Diseases
Infectious Diseases - Diagnostics



For Additional Information Please Contact:
Jeffrey James Ph.D.
NIH Office of Technology Transfer
100 N. Charles St., 5th Floor,
Baltimore, MD 21201
United States
Email: anos@mail.nih.gov


Ref No: 1890

Updated: 02/2009

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