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Proton Pump Inhibitors Increase Risk Of Heart Attacks For Patients On Common Cardiac Drug

Posted Feb 02 2009 10:46pm 1 Comment

Patients taking the common cardiac drug clopidogrel following a heart attack are at a significantly higher risk of a recurrence if they are also taking widely used acid-lowering medications called proton pump inhibitors, a new study published online in CMAJ has found (

The study, conducted over 6 years in thousands of heart attack patients aged 66 years and older, found a significantly increased risk of readmission for heart attacks if patients were taking one of several proton pump inhibitors, including omeprazole, lansoprazole, or rabeprazole. The investigators found no such association with the proton pump inhibitor pantoprazole or with other acid-lowering medications called H2 receptor antagonists.

Previous research indicates that proton pump inhibitors other than pantoprazole can block the liver’s ability to convert clopidogrel to its active form,a critical step required for clopidogrel’s anti-platelet effect.


Comments (1)
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I just started taking prevacid and I have been reading a lot about the adverse affects.  Frankly, information like this scares the bejibes out of me....  Are there any alternatives to PPI medications?

Chris Hood

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