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Protein That Fuels Lethal Breast Cancer Growth Emerges as Potential New Drug Target

Posted Oct 18 2011 7:39am

A protein in the nucleus of breast cancer cells that plays a role in fueling the growth of aggressive tumors may be a good target for new drugs, reports a research team at the Duke Cancer Institute.

The finding, published in the October 18, 2011, print issue of the journal Cancer Cell, presents a potential new way to inhibit breast cancer growth among so-called estrogen receptor negative cancers, which are especially lethal because they don’t respond to current hormone therapies.

“This is validation of a new drug target for a subset of breast cancers that have poor treatment options,” said the study’s senior author, Donald McDonnell, PhD, chairman of the Duke Department of Pharmacology and Cancer Biology.

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