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Progesterone for treatment of traumatic brain injury

Posted Dec 29 2009 12:00am
Published December 29th, 2009 in , , , , , , ,

ARRS.org - Researchers at Emory University in Atlanta, GA, recommend that progesterone (PROG), a naturally occurring hormone found in both males and females that can protect damaged cells in the central and peripheral nervous systems, be considered a viable treatment option for traumatic brain injury, according to a clinical perspective published in the January 2010 issue of the American Journal of Roentgenology.

“Traumatic brain injury (TBI) is an important clinical problem in the United States and around the world,” said Donald G. Stein, PhD, lead author of the paper. “TBI has received more attention recently because of its high incidence among combat casualties in Iraq and Afghanistan. Current Department of Defense statistics indicated that as many as 30 percent of wounded soldiers seen at Walter Reed Army Hospital have suffered a TBI, a finding that has stimulated government interest in developing a safe and effective treatment for this complex disorder,” said Stein.

“Growing evidence indicates that post-injury administration of progesterone in a variety of brain damage models can have beneficial effects, leading to substantial and sustained improvements in brain functionality. Progesterone given to both males and females can cross the blood-brain barrier and reduce edema (swelling) levels after TBI; in different models of cerebral ischemia (restriction of blood supply), significantly reduce the area of necrotic cell death and improve behavioral outcomes; and protect neurons distal to the injury that would normally die,” said Stein.

Progesterone was recently tested in two phase 2 clinical trials for traumatic brain injury and will begin a phase 3 NIH-sponsored trial for traumatic brain injuries soon.

“Given its relatively high safety profile, its ease of administration, its low cost and ready availability, progesterone should be considered a viable treatment option — especially because, in brain injury, so little else is currently available,” said Stein.

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