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Porcine Rotavirus Reassortant Compositions

Posted Feb 27 2011 7:00pm

Description of Invention:
Rotaviruses are the predominant cause of severe diarrhea and dehydration in infants and young children and are associated with approximately 600,000 deaths each year worldwide. Although death from rotavirus infection occurs more frequently in developing countries an estimated 55,000-70,000 hospitalizations and 20 to 60 deaths occur yearly in the United States. Thus, accelerating the availability of a safe and effective rotavirus vaccine represents a global public health priority.

Available for licensing and commercial development are newly developed human rotavirus-porcine rotavirus reassortant vaccine compositions and methodology for their use in humans. This technology provides immunogenic compositions of reassortant human-porcine rotaviruses with VP7 specificity of the most clinically prevalent serotypes of human rotavirus found in various regions of the world. These compositions, which need clinical evaluation, should be able to induce an immunogenic response specific to human rotavirus serotypes that is protective against symptoms of serious rotaviral disease, such as severe diarrhea and dehydration. Porcine rotaviruses are genetically more closely related to human rotavirus strains compared to rhesus and bovine rotaviruses.

Applications:
  • Resistance to developing severe human rotaviral disease
  • Safe and effective global infant vaccinations


Development Status:
Preclinical data is available at this time.

Inventors:
Yasutaka Hoshino (NIAID)
Albert Z Kapikian (NIAID)


Patent Status:
HHS, Reference No. E-056-2005/0
PCT, Application No. PCT/US2006/026901 filed 10 Jul 2006
US, Application No. 11/994,645 filed 03 Jan 2008


Relevant Publication:
  1. Y Hoshino, RW Jones, J Ross, AZ Kapikian. Porcine rotavirus strain Gottfried-based human rotavirus candidate vaccines: construction and characterization. Vaccine 2005 May 31;23(29):3791-3799. [ PubMed abs ]
  2. Gorziglia, K Nishikawa, Y Hoshino, K Taniguchi. Similarity of the outer capsid protein VP4 of the Gottfried strain of porcine rotavirus to that asymptomatic human rotavirus strains. J Virology, 1990 Jan;64(1):414-418. [ PubMed abs ]


Licensing Status:
Available for non-exclusive or exclusive licensing.


Portfolios:
Infectious Diseases
Infectious Diseases - Vaccines



For Licensing Information Please Contact:
Kevin Chang Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: changke@mail.nih.gov
Phone: 301-435-5018
Fax: 301-402-0220


Ref No: 1399

Updated: 02/2011

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