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Poor Sleep May Presage Alzheimer's Disease

Posted Mar 29 2013 10:11pm
Posted on March 29, 2013, 6 a.m. in Sleep Alzheimer's Disease

 A cross-sectional study involving cognitively normal people suggests that disturbed sleep quality may be an early sign of Alzheimer's Disease.  David Holtzman, from Washington University School of Medicine (Missouri, USA), and colleagues studied 142 men and women, ages 45 and older, who were free of cognitive impairment at the study’s start. For a two-week period, the team measured sleep via actigraphy, to obtain a measurement of sleep efficiency as the primary measure of sleep quality. The team also measured levels of beta-amyloid 42 in the cerebrospinal fluid of the subjects, to determine whether amyloid deposition was taking place. Of the subjects, 32 had elevated levels of beta-amyloid 42 in the brain; as well, the subjects had a worse sleep quality (measured as sleep deficiency) as compared to other subjects. A second measure sleep quality, wait time after sleep onset, was also higher in these 32 subjects.  The study authors report that: "Amyloid deposition in the preclinical stage of [Alzheimer's Disease] appears to be associated with worse sleep quality but not with changes in sleep quantity.”

Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM.  "Sleep Quality and Preclinical Alzheimer Disease."  JAMA Neurol. 2013 Mar 11:1-7.

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Anti-Aging Forum MLDP Join A4M
Tip #141 - Men – Get Moving
Previous studies have suggested that physical activity decreases the risk of certain cancers. University of California, Los Angeles (USA) researchers have found that men who work in jobs that require a continuous level of high physical effort are at reduced risks of developing prostate cancer. The team compared the physical activity of 392 workers who developed prostate cancer with 1,805 men similarly employed and of similar age. Amongst a group of aerospace workers, 64% of whom were involved in work that required sustained and high levels of physical activity, the odds for prostate cancer were 45% lower, as compared to their less active counterparts.

Don’t underestimate the health benefits of physical activity, be it leisure-time exercise, competitive sports, or at-work exertion. Check with your anti-aging physician to make sure the level of your physical activity is appropriate for your medical needs.
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