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Polypeptides Comprising IL-6 Ligand Binding Receptor Domains and Related Nucleic Acids, Antibodies, Compositions and Methods

Posted Jun 02 2010 5:00pm

Description of Invention:
The biological activities of IL-6 include the stimulation of B and T cell growth and differentiation, production of acute-phase proteins by hepatocytes, multilineage hematopoiesis, osteoblast formation, maturation of megakaryocytes and platelet production. An abnormal expression of IL-6 may be involved in the pathogenesis of a variety of diseases, among which are multiple myeloma, rheumatoid arthritis, postmenopausal osteoporosis, chronic autoimmune diseases, Castleman's disease and AIDS. Methods of abrogating the effects of abnormal expression of IL-6 can be made at its site of production or at its target. The inventors of this technology have focused on the latter technique. Using a unique, newly patented, automated peptide array system, the inventors have studied specific sequences potentially involved in protein-protein interactions at the molecular level. This system was used to identify and isolate potential target peptide sequences within the IL-6 receptor molecule. Candidate peptide sequences were identified by direct binding to the IL-6 ligand by optimally displayed IL-6 receptor peptide segments in solid phase form. The specific binding properties of the peptide sequences were verified by using IL-6 heteroantisera, and the peptides have been shown to mitigate or reverse the effects of the above referenced properties of IL-6 in tissue culture.

Inventors:
William C Saxinger (NCI)


Patent Status:
HHS, Reference No. E-061-1999/0


Related Technologies:
US, Patent No. 6,664,374, Issued 16 Dec 2003, Reference No. E-061-1999/1
EIR, Reference No. E-061-1999/1
US, Patent No. 7,144,986, Issued 05 Dec 2006, Reference No. E-061-1999/1



Portfolios:
Cancer
Cancer - Therapeutics
Infectious Diseases
Infectious Diseases - Therapeutics
Internal Medicine
Internal Medicine - Therapeutics



For Additional Information Please Contact:
Betty Tong Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: tongb@mail.nih.gov
Phone: 301-594-6565
Fax: 301-402-0220


Ref No: 1206

Updated: 06/2010

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