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Oxidative stress and nutritionalprevention in autoimmunerheumatic diseases

Posted Sep 11 2009 4:56pm

By Samir G. Sukkar and Edoardo Rossi

The hypothesis that oxidative stress favours flogistic and immune processes inducing autoimmune rheumaticdiseases (ARDs) and their complications is still under discussion. In this review we take into consideration boththe aetiopathological role of the diet in such diseases and the possible efficacy of dietary supports as adjuvantsfor the usual specific therapies. Moreover, we shall examine the hypothetical pathophysiological role of oxidativestress on ARDs and their complications, the methods for its evaluation and the possibility of intervening onoxidative pathways by means of nutritional modulation. It is possible that in the future we will be able to controlconnective pathology by associating an immuno-modulating therapy (‘re-educating’) with naturalproducts havingan anti-oxidant activity to current immunosuppressive treatment (which has potentially toxic effects).

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