Telomeres are the endcaps of chromosomes, the shortening of which has been associated with the aging process. Jan Kiecolt-Glaser, from Ohio State University (Ohio, USA), and colleagues enrolled overweight but healthy middle-aged and older adults in a study lasting four months. Subjects were given either 2.5 grams or 1.25 grams of omega-3 fatty acids, both of which were standardized to contain a 7:1 ratio of eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA); a placebo group served as controls. In both omega-3 supplented groups, white blood cell (leukocyte) telomeres actually lengthened; oxidative stress was reduced by about 15% (as compared to placebo). Observing that: “The data suggest that lower [omega-6:omega-3 polyunsaturated fatty acid] ratios can impact cell aging,” the study authors conclude that: “The triad of inflammation, oxidative stress, and immune cell aging represents important pre-disease mechanisms that may be ameliorated through nutritional interventions.”
Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. “Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.” Brain Behav Immun. 2012 Sep 23.
Oregon State University (US) team reveals the biological mechanism by which zinc deficiency can develop with age, leading to a decline of the immune system
University of Illinois (US) researchers have developed a new imaging tool for physicians that fits in the palm of the hand and enables an array of diagnostics
Dietary supplementation of omega-3 fatty acids may lengthen telomeres and reduce oxidative stress.
Low serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 may correlate with Alzheimer's Disease, in men
A daily glass of polyphenol-rich apple juice decreases body fat, in obese men.
The fat- and sugar-rich Western diet leads to a lifetime of health problems, dramatically increasing the risk of stroke or death at a younger age.
Daily supplementation of pterostilbene, a potent antioxidant compound found abundantly in blueberries, lowers systolic and diastolic blood pressure.
Major changes to the profile of a person’s gut bacteria environment may associate with the development of type-2 diabetes.
A diet rich antioxidant vitamins helps to reduce the risk of heart attacks, in women.
Kansas State University (US) team has developed a simple blood test that can accurately detect the beginning stages of cancer.
An active lifestyle helps to reduce the risk of glaucoma, a leading cause of blindness around the world.
Researcher team from Britain and the United States find that people who leave education with fewer qualifications are prone to age more quickly.
University of Rochester (US) scientists discover how DNA maintenance is regulated, opening the door to interventions that may enhance the body’s natural preserv
Ensuring adequate intakes of selenium may reduce the risk of age-related diseases such as cancer and heart disease,
Polyphenols present in green tea exert a potent antioxidant effect that helps to counteract free radical damage to cells.
The "longevity" protein SIRT1, known for its life-spanning effects in different species, inhibits the development of a known precursor to prostate cancer
Slowing the activity of mitochondria promotes survival and enhances longevity, in a C. elegans (roundworm) model.
Whitehead Institute researchers show that the multi-component mechanistic target of rapamycin complex 1 (mTORC1) in mammals is involved in the aging process
Boston University School of Medicine (US) researchers uncover the interaction between T-cells and monocytes that promotes a pro-inflammatory response.
UCSD (US) researchers discover Sestrin, a protein that functions as natural inhibitor of aging and age-related pathologies in a fruitfly model of aging.
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59. A Weighty Issue
Obesity and overweight are defined by Body Mass Index (BMI), the measure of body fat defined as body weight divided by the square of your height. Calculate your BMI by using the interactive U.S. National Heart, Lung, and Blood Institute's Body Mass Index calculator, at http://www.nhlbi.nih.gov/health (look under "Health Assessment Tools," and select "Body Mass Index (BMI) Calculator") [provides both Metric and US measurements]. A BMI over 25 kg/m2 is defined as overweight, and a BMI of over 30 kg/m2 as obese.
Overweight and obesity can be life threatening, in that excess weight can result in:
• Cardiovascular disease
• Type 2 diabetes
• Cancer of the breast, colon, prostrate, endometrium, kidney and gallbladder