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Omega-3 Supplementation May Slow the Aging Process

Posted Oct 26 2012 10:09pm

Telomeres are the endcaps of chromosomes, the shortening of which has been associated with the aging process.   Jan Kiecolt-Glaser, from Ohio State University (Ohio, USA), and colleagues enrolled   overweight but healthy middle-aged and older adults in a study lasting four months.  Subjects were given either 2.5 grams or 1.25 grams of omega-3 fatty acids, both of which were standardized to contain a 7:1 ratio of eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA);  a placebo group served as controls.  In both omega-3 supplented groups, white blood cell (leukocyte) telomeres actually lengthened; oxidative stress was reduced by about 15% (as compared to placebo).   Observing that: “The data suggest that lower [omega-6:omega-3 polyunsaturated fatty acid] ratios can impact cell aging,” the study authors conclude that: “The triad of inflammation, oxidative stress, and immune cell aging represents important pre-disease mechanisms that may be ameliorated through nutritional interventions.”

Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. “Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial.”  Brain Behav Immun. 2012 Sep 23.

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Anti-Aging Therapeutics 13   View the Table of Contents
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59. A Weighty Issue
Obesity and overweight are defined by Body Mass Index (BMI), the measure of body fat defined as body weight divided by the square of your height. Calculate your BMI by using the interactive U.S. National Heart, Lung, and Blood Institute's Body Mass Index calculator, at (look under "Health Assessment Tools," and select "Body Mass Index (BMI) Calculator") [provides both Metric and US measurements]. A BMI over 25 kg/m2 is defined as overweight, and a BMI of over 30 kg/m2 as obese.
Overweight and obesity can be life threatening, in that excess weight can result in:
• Cardiovascular disease
• Type 2 diabetes
• Cancer of the breast, colon, prostrate, endometrium, kidney and gallbladder
• more...
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