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Nucleotide, Deduced Amino Acid Sequence, Isolation And Purification Of Heat-Shock Chlamydial Proteins

Posted Feb 27 2011 7:00pm

Description of Invention:
This invention concerns the discovery of a novel gene that encodes the HSP60 protein from Chlamydia trachomatis, referred to as HypB in the application. This immunodominant protein is a major target for Chlamydia trachomatis vaccine development and diagnostics. This gene and protein, or fragments thereof, are useful in the development of both recombinant protein and DNA based vaccines. The recombinant protein or DNA sequence also have potential for the development of diagnostic tests for C. trachomatis. The three patent properties claim different aspects of the invention. U.S. Patent No. 5,071,962 claims monoclonal antibodies reactive against C. trachomatis HSP60 protein. U.S. Patent Application No. 07/841,323 claims the HSP60 protein and its use as a vaccine. U.S. Patent 6,423,835 claims DNA sequences, and protein fragments thereof, encoding HSP60. This DNA sequence would be useful in a DNA vaccine, alone or with the MOMP DNA sequences claimed in U.S. Patent 5,869,608 (HHS Reference No. E-003-1989/0). No foreign patent rights exist.

Richard P Morrison (NIAID)
Harlan D Caldwell (NIAID)

Infectious Diseases
Infectious Diseases - Diagnostics
Infectious Diseases - Vaccines
Rare Diseases

For Licensing Information Please Contact:
Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5515
Fax: 301-402-0220

Ref No: 111

Updated: 02/2011

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