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Novel Vaccine for Prevention and Treatment of Chlamydia Infection

Posted Feb 20 2013 7:00pm

Description of Invention:
The invention provides novel vectors, attenuated pathogens, compositions, methods and kits for preventing and/or treating chlamydia infections.

Chlamydia trachomatis is an obligate intracellular human pathogen with a unique biphasic developmental growth cycle. It's the etiological agent of trachoma, the world's leading cause of preventable blindness and the most common cause of bacterial sexually transmitted disease. C. trachomatis isolates maintain a highly conserved plasmid and naturally occurring plasmidless clinical isolates are rare, implicating its importance in chlamydial pathogenesis. Understanding the plasmid's role in chlamydial pathogenesis at a molecular level is an important objective for the future control of chlamydial infections. The NIAID inventor had studied chlamydia strains in both non-human primate and murine infectious models providing evidence that plasmids play an important role in chlamydial pathogenesis. In addition, the study results of macaque model of trachoma supports the use of plasmid-deficient organisms as novel live-attenuated chlamydial vaccines.

Applications:
Novel live-attenuated chlamydial vaccines.

Advantages:
  • Virulence attenuated vectors that can be used as vaccines against chlamydia.
  • Combination of vector with attenuated pathogenic agent improves the stability and replicative capacity of the pathogen.
  • Features nucleic acids, attenuated pathogens, compositions, methods and kits to treat and prevent chlamydia infections.


Development Status:
  • Prototype
  • In vitro data available In vivo data available (animal) In vivo data available (human)


Inventors:
Harlan D Caldwell (NIAID)


Patent Status:
HHS, Reference No. E-133-2012/0
US, Application No. 61/753,320 filed 16 Jan 2013


Relevant Publication:
  1. Song L, et al. [ PMID 23319558 ]
  2. Kari L, et al. [ PMID 21987657 ]


Collaborative Research Opportunity:
The NIAID Laboratory of Intracellular Parasites is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize chlamydia vaccine. For collaboration opportunities, please contact Harlan D. Caldwell, Ph.D. at hcaldwell@niaid.nih.gov .


For Licensing Information Please Contact:
John Stansberry Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: js852e@nih.gov
Phone: 301-435-5236
Fax: 301-402-0220


Ref No: 2536

Updated: 02/2013

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