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Novel Proteins from the Sand Fly Lutzomyia longipalpis are Potent Inhibitors of Complement Activity

Posted Jun 02 2010 5:00pm

Description of Invention:
This invention relates to the discovery that five proteins from the salivary glands of Lutzomyia longipalpis, LJM04, LJM11, LJM19, LJM26, and LJL143 have anti-complement activity. These proteins demonstrate potent inhibition of both the classical and alternative pathways for complement activation. All proteins, excluding LJM19, were shown to bind and inhibit the C3b molecule, thus inactivating an integral component of the complement pathway.

The complement system is a very important line of defense against pathogens, and is involved in many pathologies and syndromes affecting human health. It is therefore envisioned that these five novel proteins may be used to treat conditions where the complement system is involved including lupus erythematosus, juvenile arthritis, and complications associated with cardiac surgery and hemodialysis.

  • Potent inhibition of complement activity
  • Treatment of diseases involving the complement system

Development Status:
Early Stage

Jesus G Valenzuela (NIAID)

Patent Status:
HHS, Reference No. E-205-2008/0
PCT, Application No. PCT/US2009/069874 filed 30 Dec 2009

Relevant Publication:
  1. RR Cavalcante, MH Pereira, NF Gontijo. Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects. Parasitology 2003 Jul;127(Pt 1):87-93. [ PubMed abs ]

Licensing Status:
Available for licensing.

Infectious Diseases
Infectious Diseases - Diagnostics
Infectious Diseases - Therapeutics
Infectious Diseases - Vaccines
Infectious Diseases - Research Materials

For Additional Information Please Contact:
John Stansberry Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5236
Fax: 301-402-0220

Ref No: 1992

Updated: 06/2010

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