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Novel Osteobiologic Proteins for Treatment of Osteoporosis, Rheumatoid and Neurologic Diseases

Posted Jul 26 2011 8:00pm

Description of Invention:
In an effort to find effective strategies for treatment of body tissue and structural damage as the result of trauma, cancer and other diseases, scientists at the Food and Drug Administration (FDA) have identified Cartilage-Derived Morphogenetic Proteins (CDMP) and associated pathways instrumental in replacing or regenerating damaged tissue. These proteins have unique activities likely to be useful as stand alone agents or in construction of engineered tissues.

CDMPs appear helpful in the healing of bone and joint surface lesions, and also for the repair or reconstruction of cartilaginous tissues, tendons and ligaments. The invention identifies proteins belonging to TGF-Beta superfamily that promote repair of menisci, cruciate and collateral ligaments of the knee, and rotator cuff tendons. The patent application claims nucleic acids encoding human Cartilage-Derived Morphogenetic Protein-1 (hCDMP-1) variant polypeptides. Morphogenetic proteins are able to induce the proliferation and differentiation of progenitor cells into functional bone, cartilage, tendon, or ligament tissue.

  • rheumatic diseases of the bone
  • osteoporosis and osteoarthritis
  • wound healing
  • neurodegenerative disorders
  • growth and repair of musculoskeletal tissues
  • tissue engineering

Osteobiologics, such as CDMPs, have the ability to stimulate musculo-skeletal repair instead of using donated human tissue allografts and synthetic materials.

Development Status:
Early stage

Malcolm C Moos (FDA)
John T Thomas (FDA)

Patent Status:
HHS, Reference No. E-196-2004/0
US, Application No. 11/916,990 filed 08 Jul 2006

For Licensing Information Please Contact:
Surekha Vathyam Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4076
Fax: 301-402-0220

Ref No: 2298

Updated: 07/2011

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