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Novel Methods for Using Biomarkers to Monitor Glucose Levels and Screen for Diabetes Risk

Posted Sep 09 2012 8:00pm

Description of Invention:
A primary goal of diabetes therapy is to improve control of blood glucose levels (known as glycemic control) in patients. Prospective studies of both Type 1 and Type 2 diabetes indicate that careful glycemic control significantly reduces the risk of microvascular, neurological, and cardiovascular complications of diabetes. The current method of monitoring glycemic control involves measuring levels of the intracellular hemoglobin (HbA1C). However, levels of HbA1C reflect glycemic control over a timeframe of several months and are susceptible to a variety of perturbing factors such as hematologic disorders, kidney disease, aspirin or penicillin use, or alcohol intake.

This technology describes a family of novel glycated peptide and protein biomarkers for glycemic control, as well as a method to monitor glycemic control in diabetic patients. In contrast to intracellular HbA1C, this technology detects glycated plasma proteins, which may reflect changes in glycemic control more rapidly and with more sensitivity. A diagnostic test developed using this technology could be envisioned to supplement or replace current HbA1C-based glycemic monitoring and screen individuals for risk of diabetes.

Applications:
  • Diagnostic test to measure glycemic control in diabetic patients
  • Diagnostic test to screen patients for risk of developing diabetes


Advantages:
  • Detects plasma proteins rather than intracellular markers
  • May provide more rapid and sensitive detection than currently used methods


Development Status:
  • Early-stage
  • In vitro data available


Inventors:
Perry J Blackshear (NIEHS)


Patent Status:
HHS, Reference No. E-057-2005/0
US, Application No. 12/281,909 filed 05 Sep 2008



For Licensing Information Please Contact:
Tara Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: tk200h@nih.gov
Phone: 301-435-4426
Fax: 301-402-0220


Ref No: 1347

Updated: 09/2012

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