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Novel Host Target for Treatment of Hepatitis C Virus Infection

Posted Feb 20 2013 7:00pm

Description of Invention:
The subject technology is a newly discovered Interferon-lambda 4 (IFNL4) protein found through analysis of genomic data derived from primary human hepatocytes, molecular cloning and functional annotation. The IFNL4 protein is related to but distinct from other know IFNs and its expression is inducible in conditions that mimic viral infection. Preliminary studies indicate that this protein may play a role in impaired natural and treatment induced clearance of HCV. These findings suggest that the protein can potentially be a new target for treating HCV infection.

Applications:
  • Novel target for treatment of HCV infection.
  • Diagnostics can be developed for detection of IFNL4 mRNA or protein.
  • Existing biological reagents for detection of IFNL4 – expression assays, antibodies and protein.


Advantages:
IFNL4 is created by a genetic variant IFNL4-deltaG, which is present only in a subset of individuals, suggesting that IFNL4 is not an essential protein and its functional inactivation may be well-tolerated.

Development Status:
  • Early-stage
  • Pre-clinical
  • In vitro data available


Inventors:
Liudmila Prokunina (NCI)
Thomas R O'Brien (NCI)
Brian P Muchmore (NCI)
Raymond P Donnelly (FDA)


Related Technologies:
US, Application No. 61/543,620 filed 05 Oct 2011, Reference No. E-217-2011/0
PCT, Application No. PCT/US2012/59048 filed 05 Oct 2012, Reference No. E-217-2011/0


Relevant Publication:
  1. Prokunina-Olsson L, et al. [ PMID 23291588 ]


Collaborative Research Opportunity:
The NCI Division of Cancer Epidemiology & Genetics, Laboratory of Translational Genomics, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize development of tools for detection of IFNL4 mRNA and protein and modulation of its function. For collaboration opportunities, please contact John Hewes, Ph.D. at hewesj@mail.nih.gov .


For Licensing Information Please Contact:
Kevin Chang Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: changke@mail.nih.gov
Phone: 301-435-5018
Fax: 301-402-0220


Ref No: 2539

Updated: 02/2013

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