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Novel Biomarkers for Alcohol-Induced Liver Disease (ALD)

Posted Feb 21 2012 7:00pm

Description of Invention:
Alcohol-induced liver disease (ALD) is a leading cause of non accident-related deaths worldwide. ALD is reversible if identified in the early stages, but early diagnosis is difficult with existing tools. One problem associated with developing a new diagnostic tool is the genetic background associated heterogeneity in physiological responses to chronic alcohol consumption. The inventors of the present technology have solved this problem and have discovered background-independent novel biomarkers for ALD. In the current studies, the inventors generated two genetically distinct lines of PPARalpha-null mice and evaluated the levels of urine metabolites after alcohol exposure. The inventors have identified indole-3-lactic acid and phenyllactic acid as putative biomarkers for ALD. Indole-3-lactic acid and phenyllactic acid levels were significantly elevated in both lines of PPARalpha-null mice after two to three months of alcohol administration. The inventors had identified indole-3-lactic acid and phenyllactic acid to be background independent markers for ALD.

Useful for early non-invasive screening of ALD in large numbers of subjects irrespective of their genetic background.

  • Easily adaptable for the development of highly sensitive spectroscopy-based assay kits.
  • Amenable for the development of high-throughput mass spectrometric analysis of urine samples to detect early onset of ALD.

Development Status:
  • Early-stage
  • Pre-clinical
  • In vivo data available (animal)

Soumen K Manna (NCI)
Frank J Gonzalez (NCI)

Patent Status:
HHS, Reference No. E-172-2011/0
US, Application No. 61/507,573 filed 13 Jul 2011

Relevant Publication:
  1. Manna SK, et al. [ PMID 21749142 ]
  2. Manna SK, et al. [ PMID 20540569 ]

For Licensing Information Please Contact:
Suryanarayana Vepa Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5020
Fax: 301-402-0220

Ref No: 2370

Updated: 02/2012

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