Health knowledge made personal
Join this community!
› Share page:
Search posts:

New Gene Target for Alzheimer’s Disease Identified

Posted Jan 20 2014 10:08pm
Posted on Jan. 20, 2014, 6 a.m. in Alzheimer's Disease Genetics in Disease Stem Cell
New Gene Target for Alzheimer’s Disease Identified

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute (New York, USA), in collaboration with scientists at the Icahn School of Medicine at Mount Sinai (New York, USA), successfully generated a stem cell model of familial Alzheimer's disease (FAD). Using this stem cell model, researchers identified fourteen genes that may be implicated in the disease and one gene in particular that shows the importance that inflammation may play in the brain of Alzheimer's patients.  The researchers generated induced pluripotent stem (iPS) cells from affected and unaffected individuals from two families carrying PSEN1 mutations. After thorough characterization of the NPCs through gene expression profiling and other methods, they identified fourteen genes that behaved differently in PSEN1 NPCs relative to NPCs from individuals without the mutation. Five of these targets also showed differential expression in late onset Alzheimer's disease patients' brains. Therefore, in the PSEN1 iPS cell model, the researchers reconstituted an essential feature in the molecular development of familial Alzheimer's disease. PSEN1 mutations cause the most common form of inherited familial Alzheimer's disease and are one 100% penetrant, resulting in all individuals with this mutation getting the disease. The identification of genes that behaved differently in patients with the mutation provides new targets to further study and better understand their effects on the development of Alzheimer's disease. One of these genes, NLRP2, is traditionally thought of as an inflammatory gene.  The study authors submit that their model has “have reconstituted an essential feature in the molecular pathogenesis of [familial Alzheimer's disease], increased generation of [amyloid  plaques], and have characterized novel expression changes.”

Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Sam Gandy, Scott A. Noggle, et al.  "Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors.”  PLOS ONE, 8 Jan 2014.

Consuming a Mediterranean diet that is rich in extra virgin olive oil may be an effective way to protect people at high-risk for heart disease against diabetes.
A stem cell model reveals 14 genes that may be implicated in Alzheimer’s Disease. One gene suggests the role of inflammation in the brain.
What are the essential health behaviors found to help people maintain weight loss in the long term?
Americans are enjoying continuation of the steady increase that started 50 years ago.
One of the largest and longest-treatment trials involving Alzheimer's patients supports the utility and efficacy of alpha-tocopherol to slow functional decline.
Nanoparticle delivery of luteolin, a naturally occuring antioxidant, shows potential to inhibit the growth of cancer cells.
As little as one night of sleep deprivation raises markers that are linked to brain damage.
Mindfulness meditation may be useful to combat anxiety and depression, and to help manage pain.
Midlife lob-related physical and mental strain may precipitate more hospital stays later in life.
Due to significant differences in the mechanisms that cause hypertension, experts urge that women be treated earlier and more aggressively for the condition.
People with memory and thinking impairments and a history of head trauma have levels of amyloid plaques 18% higher than those with no head trauma history.
The number of people living with dementia worldwide in 2013 is now estimated at 44 million, and will reach 135 million by 2050.
Middle-aged men and women with elevated pulse pressure may be at a higher risk of having blood markers of Alzheimer's Disease later in life.
Shorter sleep duration and poorer sleep quality may raise a person's levels of beta-amyloid, an Alzheimer's disease biomarker.
Exercise may improve cognitive function in those at-risk for Alzheimer’s Disease, by improving the efficiency of brain activity associated with memory.
When is a mild slip of memory an early sign of Alzheimer’s Disease?
Researchers successfully grow a key type of human brain cell in the laboratory, and successfully transplant it for further maturation in the brains of mice.
A drug that controls type-2 diabetes may help to repair spinal cords affected by inherited neurodegenerative disease, in a mouse model.
Alzheimer’s Disease presently afflicts 5.2 million Americans with the number swelling to 13.8 million by 2050
Worse sleep quality may correlate to increased amyloid deposits in the brain, a marker of Alzheimer's Disease.
Anti-Aging Forum MLDP Join A4M
Post a comment
Write a comment:

Related Searches