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New Anti-Inflammatory Drugs Might Help Avoid Side Effects Of Steroids New Anti-Inflammatory Drugs Might Help Avoid Side Effect

Posted Oct 25 2011 10:56pm

A new class of anti-inflammatory drugs may one day serve as an alternative to steroid medications and possibly help avoid the serious side effects of steroids, based on research findings at the Salk Institute for Biological Studies.

The scientists, led by Inder M. Verma, a professor in Salk’s Laboratory of Genetics and Ronald M. Evans, the director of Salk’s Gene Expression laboratory, discovered that a protein that defends the body against cancer also plays a key role in the anti-inflammatory action of steroids. Targeting this protein might lead to new drugs that could replace or augment steroid treatment

“Steroids are the most potent anti-inflammatories available, but they can cause serious side effects,” says Verma, Salk’s American Cancer Society Professor of Molecular Biology. “We may have found a way to get around these limitations by reducing inflammation without steroids. Our findings also suggest that certain cancer patients don’t respond to steroid treatment, so they might be taking the drugs needlessly.”

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