Mucosa-associated lymphoid tissue lymphoma (MALT) of salivary glands and scleroderma: a case report
Posted Mar 09 2010 12:00am
By Monika Prochorec-Sobieszek and Colleague
The connection between scleroderma and lymphoma is uncommon and its pathogenic relationship is a much debated subject. We describe the case of a patient with mucosa-associated lymphoid tissue lymphoma (MALT) of both parotid glands without clinical signs of Sjögrens syndrome who simultaneously developed scleroderma.
Independently of the pathogenic mechanism of these two diseases, it seems very important to emphasize that scleroderma may be the first manifestation of lymphoma.
The present investigation characterises and documents the relative effectiveness of vitamin D3 (VD3) in monitoring reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione reductase (GR) activity as well as malondialdehyde (MDA) formation in hepatic tissue of Dalton's Lymphoma (DL) bearing mice.
Inoculation of DL brings about drastic induction in GSH, GPx and GR activity (128.2%, 17.04% and 63.8% respectively on the 15th day following transplantation) in association with increase in extent of lipid peroxidation. VD3 treatment maintained well controlled steady level of GSH, which although much higher than the normal control level, was 22.42% lower than that achieved in untreated DL mice.
It also produced a delayed increase in GPx and GR activity and MDA formation. Moreover VD3 has also improved survival of DL bearing mice. These observations suggest a definite and significant preventive role of VD3 and its efficacy as an antioxidant on rapidly proliferating neoplasms in mice.