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Mucin Binding Lectin Imaging Agents for Colonic Polyp Imaging

Posted Feb 29 2008 4:00pm

Description of Invention:
Available for licensing and commercial development is an imaging agent specific for colonic polyps that overexpress glycoprotein alpha-L-fucose containing mucins. Colon cancer is the second leading cause of cancer related deaths in the United States. The legume protein Ulex europaeus agglutinin I (UEA-1) has shown high specificity to alpha-L-fucose glycoproteins. Colonic mucosal neoplasia and/or polyps with high surface expression of alpha-L-fucosyl terminal residues can be specifically targeted with UEA-1 contrast agents. In one example, a computer tomography (CT) agent made from Iodine-127 (127I) labeled UEA-1 (I-UEA-1) and encapsulated into polymeric liposome nanoparticles was used to image murine colonic polyps. Ideally, the inventors envision a contrast agent that can be administered orally (e.g., liquid or pill form) and that would eliminate a patient’s need to drink harsh enema/contrast solutions prior to CT imaging.

Applications:
  • Colon cancer
  • Cancer imaging
  • Contrast agents
  • CT colonography


Inventors:
Ronald M Summers (CC)
Jianwu Xie (CC)
Celeste A Roney (CC)


Patent Status:
HHS, Reference No. E-254-2007/0
US, Application No. 61/064,086 filed 15 Feb 2008
US, Application No. 12/371,472 filed 13 Feb 2009


Relevant Publication:
  1. J Xie et al. Oral contrast enhanced MicroCT virtual colonoscopy of APC knockout mouse colon polyp model. Gastroenterology. 2007 Apr;132(4), Suppl. 1, Abstract No. M1063, pp A-353 – A-354.
  2. C Roney et al. Glycoprotein expression by adenomatous polyps of the colon. Proc. SPIE, Vol 6916, 691601 (2008); Published online 12 March 2008, doi:10.1117/12.769224.
  3. SD O’Connor et al. Oral contrast adherence to polyps on CT colonography. J Comput Assist Tomogr. 2006 Jan-Feb;30(1):51-57. [ PubMed abs ]


Licensing Status:
Available for licensing.


Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Diagnostics
Nanotechnology



For Additional Information Please Contact:
Jeffrey James Ph.D.
NIH Office of Technology Transfer
100 N. Charles St., 5th Floor,
Baltimore, MD 21201
United States
Email: anos@mail.nih.gov


Ref No: 1725

Updated: 03/2008

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