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Mouse Monoclonal Antibody Targeting Human NOX1, a Target for Cancer and Inflammation

Posted Apr 29 2012 8:00pm

Description of Invention:
Available for licensing is a mouse monoclonal antibodies targeting human nicotinamide adenine dinucleotide phosphate-oxidase (NAPH) oxidase 1 (NOX1) enzyme. NOX mediates the homeostasis of reactive oxygen species, which play a critical regulatory role in cancer cell signal transduction and tumor cell differentiation. NOX1-generated hydrogen peroxide can trigger an “angiogenic switch” that includes the induction of angiogenic factors that promote tumor cell vascularization. Additionally, NOX1 may play a role in inflammation.

Investigators at the National Cancer Institute found NOX1 is significantly expressed more in colon and gastric cancers compared with adjacent normal bowel and gastric mucosa respectively. To the best of NIH's knowledge, this is the only monoclonal antibody that can be used to detect human NOX1. This antibody detects endogenous levels of the NOX1 protein and could potentially be used in biochemical laboratory studies as well as diagnostic tests that involve the functional significance of NOX1 in human physiology and pathophysiology, particularly its role in cancer and inflammation.

  • Research tool to study cancer and inflammation
  • Method to diagnose colon and gastric cancer
  • Treatment for cancer and inflammation

To the best of NIH's knowledge, this is the only available monoclonal antibody to detect human NOX1.

Development Status:
  • Early-stage
  • In vitro data available

James H Doroshow (NCI)
Krishnendu K Roy (NCI)
Guojian Jiang (NCI)
Jaimo Lu (NCI)
Smitha Antony (NCI)

Patent Status:
HHS, Reference No. E-097-2012/0

Research Tool — Patent protection is not being pursued for this technology.

For Licensing Information Please Contact:
Sabarni Chatterjee Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5587
Fax: 301-402-0220

Ref No: 2422

Updated: 04/2012

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