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Mouse Monoclonal Antibodies to MAD1, a Human Spindle Assembly Checkpoint Protein for Maintaining Chromosomal Segregation

Posted Feb 14 2013 7:00pm

Description of Invention:
Scientists at the National Institutes of Health have developed mouse monoclonal antibodies against the human spindle assembly checkpoint protein, MAD1. The spindle assembly checkpoint in mitotic cell division regulates the fidelity of chromosome segregation during cell division. MAD1 is an important component of this checkpoint control, which if compromised, can lead to the initiation of cancer cell growth. These monoclonal antibodies are the first available antibodies against MAD1 and can be used in laboratory research and diagnostics.

  • Research tool in various laboratory procedures to identify and detect MAD1
  • Diagnostic tool for aneuploidy, the condition of having an abnormal number of chromosomes, which results in birth and dev delopmental defects, such as Down syndrome

Kuan-teh Jeang (Estate) (NIAID)

Patent Status:
HHS, Reference No. E-119-2003/0

Research Tool -- Patent protection is not being pursued for this technology

Relevant Publication:
  1. K Haller et al. The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint. Oncogene 2006 Apr 6;25(15):2137-2147. [ PubMed abs ]

Licensing Status:
Available for licensing under a Biological Materials License Agreement.

Collaborative Research Opportunity:
The NIAID Office of Technology Development is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize reagents for studying cell cycle checkpoint factors. Please contact Agnes Rooke at or by phone at 301-594-1697 for more information.

For Licensing Information Please Contact:
Samuel Bish Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5282
Fax: 301-402-0220

Ref No: 1884

Updated: 02/2013

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