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Mouse Monoclonal Antibodies Against Human IKKgamma/NEMO Protein

Posted May 31 2003 5:00pm

Description of Invention:
NF-kB has been found to be important in immune responses, cell proliferation, apoptosis, and in organ development. Several years ago it was discovered that an IKKgamma/NEMO protein was essential as an adaptor molecule to mediate TNF-alpha, IL-1, and oncoprotein induced activation of NF-kB. Mutation in IKKgamma/NEMO also results in two human genetic diseases, Familial incontinentia pigmenti and hypohidrotic/anhidrotic ectodermal dysplasia. The NIH announces mouse monoclonal antibodies to IKKgamma/NEMO that are far superior to other immunological reagents. It is anticipated that the antibodies would have both research and diagnostic capabilities.

Inventors:
Kuan-teh Jeang (NIAID)


Patent Status:
HHS, Reference No. E-118-2003/0



Portfolios:
Internal Medicine
Internal Medicine - Diagnostics
Internal Medicine - Research Materials
Research Materials



For Additional Information Please Contact:
Tara Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: tk200h@nih.gov
Phone: 301-435-4426
Fax: 301-402-0220


Ref No: 743

Updated: 06/2003

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