Description of Invention: This mouse has been generated by targeted gene disruption. The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). As an example, the mouse is in use in the study of atherosclerosis. Further, the mouse may serve as a model study the role of the immune system during infection with pathogens as well as other immunologically mediated diseases and responses to tumors.
Inventors: Ji-liang Gao (NIAID) Philip M Murphy (NIAID)
Patent Status: HHS, Reference No. E-216-2003/0
Research Tool -- patent protection is not being pursued for this technology
C Combadière et al. Decreased atheroscelerotic lesion formation in CX3R1/apolipoprotein E double knockout mice. [ PubMed: 12600915 ]
Licensing Status: Available for licensing under a biological materials license.
Portfolios: Cancer Cancer - Diagnostics Research Materials
For Additional Information Please Contact: Susan Ano Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: firstname.lastname@example.org Phone: 301-435-5515 Fax: 301-402-0220