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Mouse Lacking the Chemokine Receptor CX3CR1

Posted Feb 28 2010 4:00pm

Description of Invention:
This mouse has been generated by targeted gene disruption. The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). As an example, the mouse is in use in the study of atherosclerosis. Further, the mouse may serve as a model study the role of the immune system during infection with pathogens as well as other immunologically mediated diseases and responses to tumors.

Inventors:
Ji-liang Gao (NIAID)
Philip M Murphy (NIAID)


Patent Status:
HHS, Reference No. E-216-2003/0

Research Tool -- patent protection is not being pursued for this technology

Relevant Publication:
  1. C Combadière et al. Decreased atheroscelerotic lesion formation in CX3R1/apolipoprotein E double knockout mice. [ PubMed: 12600915 ]


Licensing Status:
Available for licensing under a biological materials license.


Portfolios:
Cancer
Cancer - Diagnostics
Research Materials



For Additional Information Please Contact:
Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: anos@mail.nih.gov
Phone: 301-435-5515
Fax: 301-402-0220


Ref No: 788

Updated: 03/2010

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