Monomeric And Dimeric Arylisoquinoline Alkaloids And Derivatives Thereof

Description of Invention:
This invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric arylisoquinoline alkaloid derivatives. The present invention furthermore provides novel dimeric arylisoquinoline alkaloids comprised of coupled first and second arylisoquinoline monomers, wherein either or both of said monomer(s) is (are) monomeric compound(s) of the present invention. Monomeric and dimeric compounds of the present invention have medically useful properties, such as antimicrobial properties, more specifically antimalarial and antiviral properties. Monomeric compounds of the present invention are also useful as building blocks or intermediates for synthesis of novel dimeric arylisoquinoline alkaloids.

Inventors:
Michael R Boyd (NCI)


Patent Status:
HHS, Reference No. E-200-1994/2
PCT, Application No. PCT/US98/27407 filed 23 Dec 1998



Portfolios:
Infectious Diseases
Infectious Diseases - Therapeutics
In-vitro Data



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Ref No: 332

Updated: 02/2011