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Monoclonal Antibodies to the Tumor-Specific Antigen, Human ROR1

Posted Aug 16 2012 8:00pm

Description of Invention:
B-cell chronic lymphocytic leukemia (B-CLL) is an incurable disease developed by more than 15,000 Americans each year and currently, there are no therapeutic monoclonal antibodies (mAbs) that specifically recognize B-CLL tumor cells. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a constitutively expressed tumor-specific cell surface antigen and an ideal target for therapeutic antibodies.

Available for licensing are mouse anti-human ROR1 monoclonal antibodies (hybridomas designated 2D11, 1A1, and 1A7). All mAbs bind to ROR1 on the surface of primary human B-CLL cells and have good potential for therapeutic development by either humanization, conversion to chimeric mouse/human antibodies, or conjugation to a radioisotope, chemical drug or bacterial toxin to B-CLL and breast cancer.

Applications:
  • Therapeutic antibodies against ROR1-expressing cancers like B-CLL and possibly other hematologic and solid malignancies
  • Research tools for the study of ROR1 in cancer biology


Advantages:
  • Hybridomas provide a continuous source of mAb
  • Target extracellular domain of ROR1


Inventors:
Christoph Rader (NCI)
Sivasubramanian Baskar (NCI)


Patent Status:
HHS, Reference No. E-274-2008/0

Research Tool — Patent protection is not being pursued for this technology.

Relevant Publication:
  1. Baskar S, et al. [ PMID 18223214 ]


Collaborative Research Opportunity:
The National Cancer Institute, Experimental Transplantation and Immunology Branch, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize diagnostic or therapeutic mAbs against ROR1. Please contact John D. Hewes, Ph.D. at 301-435-3121 or hewesj@mail.nih.gov for more information.


For Licensing Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: wongje@mail.nih.gov
Phone: 301-435-4633
Fax: 301-402-0220


Ref No: 1867

Updated: 08/2012

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