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Monoclonal Antibodies That Recognize the Human Type I Interferon Receptor and Block Interferon Signaling

Posted Aug 21 2013 8:00pm

Description of Invention:
Type I interferons play a critical role in both innate and adaptive immunity through the stimulation of the IFNAR1 which initiates interferon signaling in response to viral and bacterial infections. However, abnormal interferon signaling is associated with human diseases, such as lupus. The present invention discloses six hybridomas that produce mouse monoclonal antibodies specific for the extracellular domain of human IFNAR1. Two of the monoclonal antibodies are able to bind IFNAR1 and reduce interferon signaling. As such, they can be utilized as a research tool for studying the expression of IFNAR1 and the inhibition of IFNAR1 function in humans or possibly as therapeutic reagents for human diseases.

Applications:
  • Research reagents for studying the expression and signaling of IFNAR1.
  • A potential therapeutic reagent.


Advantages:
  • Specific for the extracellular domain of human IFNAR1. Can therefore specifically recognize receptor expressed on the cell surface.
  • Bind IFNAR1 and reduce interferon signaling


Development Status:
  • Pilot
  • In vitro data available


Inventors:
Sonja M Best (NIAID)
Kirk Lubick (NIAID)
Shelly J Robertson (NIAID)


Patent Status:
HHS, Reference No. E-527-2013/0

Research Material – Patent protection is not being pursued for this technology.

Relevant Publication:
  1. Goldman LA, et al. [ PMID 10048764 ]
  2. Benoit P, et al. [ PMID 8423335 ]


Collaborative Research Opportunity:
The National Institute of Allergy and Infectious Diseases (NIAID) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize human type I interferon receptor antibodies. For collaboration opportunities, please contact Alicia Evangelista at alicia.evangelista@nih.gov or 301-594-1673.


For Licensing Information Please Contact:
Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: anos@mail.nih.gov
Phone: 301-435-5515
Fax: 301-402-0220


Ref No: 2616

Updated: 08/2013

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