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Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme

Posted Apr 19 2012 12:00am

Description of Invention:
Available for licensing are monoclonal antibodies targeting human DNA polymerase beta (Pol B). Pol B is a constitutively expressed "housekeeping" enzyme that plays a role in base excision repair (BER), a cellular defense mechanism that repairs DNA base damage and loss. Aberrant Pol B expression is associated with genomic instability indicating that Pol B is required for DNA maintenance, replication and recombination.

These antibodies can be utilized to elucidate BER's mechanism of action and Pol B's structure and function. Moreover, the antibodies can be used to detect Pol B in samples with a variety of techniques including immunoblotting, ELISA, immunoprecipitation, and immunohistochemistry.

Applications:
  • Research tool to elucidate the mechanism of base excision repair
  • Research reagents


Advantages:
Can be utilized in a variety of applications to study Pol B

Development Status:
  • Early-stage
  • In vitro data available


Inventors:
Samuel H Wilson (NIEHS)
Rajendra Prasad (NIEHS)


Patent Status:
HHS, Reference No. E-036-2008/0

Research Tool — Patent protection is not being pursued for this technology.

Relevant Publication:
  1. Srivastava DK, et al. [ PMID 7608211 ]
  2. Singhal R, et al. [ PMID 7822335 ]
  3. Prasad R, et al. [ PMID 8663274 ]
  4. Piersen C, et al. [ PMID 8663612 ]
  5. Sobol R, et al. [ PMID 12713817 ]
  6. Poltoratsky V, et al. [ PMID 17127106 ]


Collaborative Research Opportunity:
The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize these monoclonal antibodies. For collaboration opportunities, please contact Elizabeth M. Denholm, Ph.D. at denholme@niehs.nih.gov .


For Licensing Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: wongje@mail.nih.gov
Phone: 301-435-4633
Fax: 301-402-0220


Ref No: 2401

Updated: 04/2012

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