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Milk Thistle Compound Helps to Protect Against Skin Cancer

Posted Feb 21 2013 10:10pm
Posted on Feb. 19, 2013, 6 a.m. in Cancer Botanical Agents Skin-Hair

UVA radiation (315–400 nm), which constitutes approximately 95% of the UV irradiation in natural sunlight reaching earth surface, is a major environmental risk factor associated with human skin cancers.  Rajesh Agarwal, from the University of Colorado Cancer Center (Colorado, USA), and colleagues subjected human skin cells pretreated with silibinin to UVA radiation.  The team observed that the rate at which these damaged cells died increased dramatically.  Specifically, the study shows that pretreatment with silibinin resulted in higher release of reactive oxygen species (ROS) within the UVA-exposed cells, leading to higher rates of cell death.  The study authors conclude that: “These results suggest that silibinin may be beneficial in the removal of UVA-damaged cells and the prevention of skin cancer.”

Sreekanth Narayanapillai, Chapla Agarwal, Cynthia Tilley, Rajesh Agarwal. “Silibinin Is a Potent Sensitizer of UVA Radiation-induced Oxidative Stress and Apoptosis in Human Keratinocyte HaCaT Cells.”  Photochemistry and Photobiology, Volume 88, Issue 5, September/October 2012, Pages: 1135–1140.

  
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Anti-Aging Forum MLDP Join A4M
Tip #127 - Delay Death with Vitamin D
The therapeutic role of vitamin D, "the sunshine vitamin," for bone health, has become well established. A number of recent studies now link vitamin D deficiency to adverse health consequences such as cancer, cardiovascular disease, high blood pressure, type 2 diabetes, and some infectious diseases.

Johns Hopkins University (Maryland, USA) researchers reported that low blood levels of Vitamin D are associated with a 26% increased risk of death from any cause. The team analyzed data collected on 13,331 adults during a 6-year period after which the subjects were followed for 9 years. People with Vitamin D levels of less than 17.8 ng/mL had a 26% increased rate of death from any cause, compared to people with the highest Vitamin D levels (more than 32.1 ng/mL).

Researchers from Harvard School of Public Health (Massachusetts, USA) reported that those individuals taking vitamin D supplements are at a 7% lower risk of death, as compared to those who did not supplement.

As well, Vitamin D inhibits the body’s inflammatory response and thus reduces the turnover of leukocytes (a type of white blood cell). The length of the leukocyte telomere (the endcap of the chromosome) is a predictor of aging-related disease, whereby it shortens as a result of increased inflammation. A team from King's College, London School of Medicine (United Kingdom) found that people with longer telomeres have higher levels of Vitamin D stored in their bodies. The team reports that: “The difference … was … equivalent to five years of telomeric aging,” suggesting that people who have higher levels of vitamin D may age more slowly than people with lower levels.
 
 
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