Methods of Inducing Deacetylase Inhibitors to Promote Cell Differentiation and Regeneration

Description of Invention:
The present invention discloses a method of enhancing progenitor cell differentiation, including enhancing myogenesis, neurogenesis and hematopoiesis, by contacting a progenitor cell with an effective amount of a deacetylase inhibitor (DI). The progenitor cell can be part of cell culture, such as a cell culture used for in vitro or in vivo analysis of progenitor cell differentiation, or can be part of an organism, such as a human or other mammal. Contacting the progenitor cell with a DI can lead to enhancement of expression of terminal cell-type specific genes in the progenitor cell, such as enhancing expression of muscle-specific genes in myoblasts, and can lead to skeletal muscle hypertrophy. Administering a DI to a subject also can provide some prophylactic or therapeutic effect for inhibiting, preventing, or treating associated with a degeneration or loss of tissue. The DI can be administered to a subject as part of a pharmaceutical composition.

Inventors:
Vittorio Sartorelli (NIAMS)


Patent Status:
HHS, Reference No. E-353-2001/0
HHS, Reference No. E-353-2001/1
HHS, Reference No. E-353-2001/2
US, , Patent No. 7,229,963, Issued 12 Jun 2007
US, Application No. 11/800,151 filed 04 May 2007



Portfolios:
Internal Medicine
Internal Medicine - Diagnostics
Internal Medicine - Research Materials



For Additional Information Please Contact:
Suryanarayana Vepa Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: vepas@mail.nih.gov
Phone: 301-435-5020
Fax: 301-402-0220


Ref No: 640

Updated: 11/2002