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Methods for Treating Cancer in Humans Using IL-21

Posted May 31 2011 8:00pm

Description of Invention:
The present invention discloses the use of IL-21 for cancer therapy and/or cancer prevention. When compared to similar cytokines, IL-21 has shown substantial anticancer activity and reduced toxicity in murine models.

IL-21 belongs to the class I family of cytokines and is closely related to IL-2 and IL-15. Some cancer patients have shown significant response to administration of IL-2. However, IL-2 has also been associated with severe toxicity leading to a variety of undesirable side effects. This invention attempts to resolve the toxicity concerns and presents a new therapy for cancer prevention and treatment.

Applications:
Method to treat and prevent cancer

Advantages:
Targeted therapy to minimize negative side effects of IL-2 cancer therapeutics

Development Status:
Pre-clinical

Inventors:
Patrick Hwu (NCI)
Gang Wang (NCI)
Warren J Leonard (NHLBI)
Rosanne Spolski (NHLBI)


Patent Status:
HHS, Reference No. E-137-2002/0
US, Application No. 12/651,858 filed 04 Jan 2010


Relevant Publication:
  1. Spolsi R, Leonard WJ. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol. 2008;26:57-79. [ PMID: 17953510 ]
  2. Leonard WJ, Spolski R. Interleulin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol. 2005 Sep;5(9):688-698. [ PMID: 16138102 ]
  3. Wang G, et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res. 2003 Dec15;63(24):9016-9022. [ PMID: 14695220 ]
  4. Spolski R, Leonard WJ. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol. 2008 Jun;20(3):295-301. [ PMID: 18554883 ]


Licensing Status:
Available for licensing


Portfolios:
Cancer
Cancer - Therapeutics



For Licensing Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: wongje@mail.nih.gov
Phone: 301-435-4633
Fax: 301-402-0220


Ref No: 619

Updated: 06/2011

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