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Methods For Treating Autoimmune Diseases And Transplantation Rejection

Posted Jun 02 2010 5:00pm

Description of Invention:
Methods for treating autoimmune diseases by suppressing the expression of the major histocompatibility complex (MHC) class I molecules by administering either methimazole, methimazole derivatives, carbimazole, propylthiouracil, thionamides, thiourelylenes, thioureas, and thiourea derivatives. These compounds can be used to treat diseases such as rheumatoid arthritis, psoriasis, juvenile diabetes, primary idiopathic myxedema, myasthenia gravis, scleroderma, De Quervains thyroiditis, systemic lupus erythematosus dermatomyositis, polyarteritis nodosa, and polymyositis. This invention also provides the means for inhibiting transplantation rejection in humans. Also provided are in vivo and in vitro means for assessing and developing drugs capable of suppressing the MHC class I molecules.

Dinah S Singer (NCI)
Leonard D Kohn (NIDDK)
Edna Mozes (NCI)
Motoyasu Saji (NIDDK)

Patent Status:
HHS, Reference No. E-068-1993/0
US, , Patent No. 5,556,754, Issued 17 Sep 1996
US, , Patent No. 5,871,950, Issued 16 Feb 1999
HHS, Reference No. E-068-1993/0
PCT, Application No. PCT/US94/06422 filed 07 Jun 1994

Internal Medicine
Internal Medicine - Therapeutics

For Additional Information Please Contact:
Tara Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4426
Fax: 301-402-0220

Ref No: 289

Updated: 06/2010

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