Methods For Treating Autoimmune Diseases And Transplantation Rejection
Posted Jun 02 2010 5:00pm
Description of Invention: Methods for treating autoimmune diseases by suppressing the expression of the major histocompatibility complex (MHC) class I molecules by administering either methimazole, methimazole derivatives, carbimazole, propylthiouracil, thionamides, thiourelylenes, thioureas, and thiourea derivatives. These compounds can be used to treat diseases such as rheumatoid arthritis, psoriasis, juvenile diabetes, primary idiopathic myxedema, myasthenia gravis, scleroderma, De Quervains thyroiditis, systemic lupus erythematosus dermatomyositis, polyarteritis nodosa, and polymyositis. This invention also provides the means for inhibiting transplantation rejection in humans. Also provided are in vivo and in vitro means for assessing and developing drugs capable of suppressing the MHC class I molecules.
Inventors: Dinah S Singer (NCI) Leonard D Kohn (NIDDK) Edna Mozes (NCI) Motoyasu Saji (NIDDK)
Portfolios: Internal Medicine Internal Medicine - Therapeutics
For Additional Information Please Contact: Tara Kirby Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: firstname.lastname@example.org Phone: 301-435-4426 Fax: 301-402-0220