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Methods for Promoting Stem Cell Proliferation and Survival

Posted Jun 15 2010 5:00pm

Description of Invention:
Regenerative medicine has the potential to treat numerous human diseases and afflictions including neurodegenerative disorders and spinal cord injury that are typically insidious and worsen over time. This technology consists of a promising treatment method that coaxes stem cells into a state that promotes survival and proliferation. Two critical elements of this approach involve identifying the target niche and determining the pharmacological agents that can be used to promote stem cell regeneration.

Specifically, this technology consists of a method to activate the endogenous neural stem cells (NSCs) to promote their survival and yield using angiopoietin-2 and a cocktail of ligands and growth factors. This method has demonstrated that it can significantly improve the yield of stem cell cultures in vitro and stimulate behavioral recovery in a model of Parkinson's disease in vivo. This method is applicable to a variety of stem cell types including embryonic stem cells, adult spinal cord cells, and pericyctes from blood vessels.

Applications:
Possible applications for this technology include:
  • Method for culturing stem cells for optimal regeneration.
  • Treatment of neurological diseases and disorders such as Parkinson's disease, stroke, diabetes-related neuropathies, and spinal cord.
  • Diagnostic assays to determine proliferation or inhibition of stem cells.


Development Status:
Pre-clinical

Inventors:
Andreas Androutsellis-Theotokis (NINDS)
Ronald D McKay (NINDS)


Patent Status:
HHS, Reference No. E-182-2007/0
US, Application No. 12/673,576 filed 15 Feb 2010


Relevant Publication:
  1. A Androutsellis-Theotokis, RR Leker, F Soldner, DJ Hoeppner, R Ravin, SW Poser, MA Rueger, SK Bae, R Kittappa, RD McKay. Notch signaling regulates stem cell numbers in vitro and in vivo. Nature. 2006 Aug 17;442(7104):823-826. [ PubMed abs ]


Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The National Institute of Neurological Disorders and Stroke is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize agents with activity on proliferation and/or differentiation of stem cells. Please contact Laurie Arrants at 301-435-3112 or ArrantsL@ninds.nih.gov or Martha Lubet at 301-435-3120 or lubetm@mail.nih.gov for more information.


Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Diagnostics
Central Nervous System
Central Nervous System - Therapeutics
In-vivo Data



For Additional Information Please Contact:
Fatima Sayyid MHPM
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 21,
Rockville, MD 20852
United States
Email: Fatima.Sayyid@nih.hhs.gov
Phone: 301-435-4521
Fax: 301-402-0220


Ref No: 1789

Updated: 06/2010

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