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Methods and Composition for Identification of Variants of JC Virus DNA; An Etiologic Agent for Progressive Multifocal Leukoencep

Posted Jan 10 2013 7:00pm

Description of Invention:
JC Virus causes a fatal disease in the brain called progressive multifocal leukoencephalopathy (PML) that occurs in many patients with immunocompromised conditions. The finding of JCV DNA in the patients with neurological symptoms of PML is a diagnostic criterion and is needed to confirm the diagnosis of PML to rule out other neurological conditions. Certain JC virus variants are known to have a greater association with PML. For example, "Prototype" JC virus is far more pathogenic than "Archetype" JC virus.

This invention claims novel assays for identifying Archetype and/or Prototype JC virus by detecting the presence or absence of the unique Archetype nucleic acid sequence in the non-coding regulatory region of JC virus. While the sequences of Archetype and Prototype JC virus are known, these are the first assays that allow discrimination between Prototype and Archetype JC virus in a simple assay without the need for DNA sequencing. The identification of a JC virus as a prototype can lead to early treatment of infected individuals.

Applications:
  • JCV diagnostic kits.
  • JCV diagnostics.


Advantages:
  • DNA sequencing not required.
  • Single assay format using same template to identify prototype and archetype with 10c/ml sensitivity.


Development Status:
  • Clinical
  • In vitro data available
  • In vivo data available (human)


Inventors:
Eugene O Major (NINDS)
Caroline F Ryschkewitsch (NINDS)


Patent Status:
HHS, Reference No. E-088-2012/0
US, Application No. 61/661,289 filed 18 Jun 2012


Related Technologies:
EIR, Reference No. E-152-2009/0


Research Material — Patent protection is not being pursued for this technology.

Relevant Publication:
  1. Perkins MR, et al. [ PMID 23144619 ]


Collaborative Research Opportunity:
The National Institute of Neurological Disorders and Stroke is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize assays for the detection of JC Virus. For collaboration opportunities, please contact Melissa Maderia at maderiam@mail.nih.gov or 301-451-3943.


For Licensing Information Please Contact:
Peter Soukas J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 14,
Rockville, MD 20852-3804
United States
Email: soukasp@mail.nih.gov
Phone: 301-435-4646
Fax: 301-402-0220


Ref No: 2507

Updated: 01/2013

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