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Method to Disrupt Protein-Protein Interactions and its Use to Identify Compounds Able to Inhibit HIV-1 Rev Protein Multimerizati

Posted Jun 02 2010 5:00pm

Description of Invention:
The invention provides a FRET-based assay for the study of Rev-Rev interaction in vitro, based on YFP and CFP expression constructs for Rev. Using this assay, Rev-derived small peptides that can inhibit Rev-Rev interactions and disrupt dimerization were discovered. This assay can be used as an in vitro assay for studying protein-protein interactions in general, and for the discovery of inhibitors or agonists of such interactions as potential drugs against HIV infections, as well as for the discovery of Rev dimerization inhibitors. Thus this assay can be useful for drug screening.

Inventors:
George N Pavlakis (NCI)
Leonid Suvorov (NCI)


Patent Status:
Research Tool -- patent protection is not being pursued for this technology

Licensing Status:
Available for licensing through a Biological Materials License (BML) or though a Material Transfer Agreement (MTA).

Collaborative Research Opportunity:
In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.


Portfolios:
Infectious Diseases
Infectious Diseases - Research Materials
In-vitro Data



For Additional Information Please Contact:
Sally Hu Ph.D., M.B.A.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 21,
Rockville, MD 20852
United States
Email: hus@mail.nih.gov
Phone: 301-435-5606
Fax: 301-402-0220


Ref No: 1236

Updated: 06/2010

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