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Method for Promoting Stem Cell Proliferation and Survival

Posted Jun 02 2010 5:00pm

Description of Invention:
This technology describes a method to promote stem cell survival and proliferation by manipulating the phosphorylation state of Stat3 protein. This method has been shown to enhance survival and proliferation in stem cell cultures in vitro, and also in neuronal precursor cells in vivo. The methods include use of a Notch ligand and growth factors such as FGF-2 or insulin to promote neural stem cell survival and proliferation. The technology is also directed to a population of stem cells expressing STAT3 phosphorylated at serine 727.

Applications:
  • Clinical treatment for stroke and other neurodegenerative diseases by administration of agents that promote stem cell survival and proliferation.
  • Increased generation of stem cells in vitro.
  • Screening assays for agents that promote proliferation of stem cells or inhibit proliferation of cancer cells.
  • Diagnostic assay for cancer to determine the phosphorylation state of the protein in tumors.


  • Development Status:
    • A method of increasing proliferation and survival of stem cells or precursor cells in vitro has been developed. The cells produced by this method have been described in an article in Nature 2006 Aug 17;442(7104):823-826.
    • The method of increasing proliferation and survival of stem cells is efficacious in in vivo rodent models of Parkinson's disease and stroke.


    Inventors:
    Ronald D McKay (NINDS)
    Andreas Androutsellis-Theotokis (NINDS)


    Patent Status:
    HHS, Reference No. E-239-2005/0
    US, Application No. 60/715,935 filed 08 Sep 2005
    CA, Application No. 2621161 filed 07 Sep 2006
    US, Application No. 12/066,075 filed 06 Mar 2008


    Relevant Publication:
    1. A Androutsellis-Theotokis et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 2006 Aug 17;442(7104):823-826. [ PubMed abs ]


    Licensing Status:
    Available for non-exclusive or exclusive licensing.

    Collaborative Research Opportunity:
    The National Institute of Neurological Disorders and Stroke, Laboratory of Molecular Biology, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize agents that inhibit or induce phosphorylation of STAT3 protein and survival of stem cells and precursor cells. Please contact Martha Lubet at 301/435-3120 or lubetm@mail.nih.gov .


    Portfolios:
    Devices/Instrumentation
    Devices/Instrumentation - Diagnostics
    Internal Medicine
    Internal Medicine - Diagnostics
    Central Nervous System
    Central Nervous System - Therapeutics
    In-vitro Data



    For Additional Information Please Contact:
    Fatima Sayyid MHPM
    NIH Office of Technology Transfer
    6011 Executive Blvd. Suite 325 Room 21,
    Rockville, MD 20852
    United States
    Email: Fatima.Sayyid@nih.hhs.gov
    Phone: 301-435-4521
    Fax: 301-402-0220


    Ref No: 1328

    Updated: 06/2010

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