Health knowledge made personal
Join this community!
› Share page:
Search posts:

Menopausal HRT Does Not Prevent Chronic Disease

Posted Oct 23 2013 10:07pm

Researchers have carried out an extended post-intervention follow-up of the 2 Women’s Health Initiative (WHI) trials in order to investigate the effects of menopausal hormone therapy on chronic disease. JoAnn E. Manson, M.D., Dr.P.H., of Brigham and Women's Hospital, Boston, and colleagues examined data from 27,347 postmenopausal women, ages 50 through 79 years, who were enrolled at 40 US centers in 1993. Women with an intact uterus received conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) or placebo . Whereas women with prior hysterectomy received CEE alone or placebo. The intervention lasted an average of 5.6-years in the CEE plus MPA trial, and 7.2-years in the CEE alone trial, with 6-8 additional years of follow-up until September 30, 2010. Results showed that the risks of CEE+MPA during intervention outweighed the benefits. Postintervention, most risks and benefits had dissipated, although some elevation in breast cancer risk persisted during follow-up. For CEE, the benefits and risks during the intervention phase were more balanced, although analysis of postintervention date revealed a significant decrease in breast cancer risk. Neither regimen affected all-cause mortality. The authors concluded: "In summary, current WHI findings based on results from the intervention, postintervention, and cumulative posttrial stopping phases do not support the use of either estrogen-progestin or estrogen alone for chronic disease prevention."

JE Manson, RT Chlebowski, ML Stefanick, AK Aragaki, JE Rossouw, RL Prentice, et al. "Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials." JAMA. 2013, October 2.

Yoga may help to improve sleep in menopausal women, but has no effect on hot flashes or night sweats.
Newly identified anti-tau antibodies have been shown to prevent the accumulation of toxic tau proteins in the brains of mice.
People who are depressed may have a significantly higher risk of developing Parkinson's disease.
Chronic treatment with the statin pravastatin has been shown to impair learning and object recognition in an animal study.
Results of an extended follow-up of the 2 Women's Health Initiative hormone therapy trials does not support the use of hormones for chronic disease prevention,
Researchers warn that antidepressant drugs may be an independent risk factor for type 2 diabetes.
People following a moderate exercise program are more motivated and have higher energy levels than those following a more intensive program.
Compounds found in red grapes and blueberries have been shown to increase the expression of a gene involved in immune function.
Taking supplementary vitamin B may lower the risk of stroke by as much as 7%.
Research shows that the average 25-year-old American today can expect 2.4 more years of a healthy life than 20-years ago.
Research suggests that exercise reduces a woman’s breast cancer risk by increasing the production of “good” estrogen metabolites.
Higher dietary intake of pyridoxine (Vitamin B6) associates with reduced risk of hip fracture, among women.
DHEA (dehydroepiandrosterone), a hormone secreted by the adrenal glands, helps to alleviate menopausal symptoms.
Study results suggest that regularly taking certain supplements, including multivitamins, folic acid, iron, and copper, may increase the risk of death in older
Engaging in regular physical activity is associated with less decline in cognitive function in older adults.
UK study reveals that tall women may be at greater overall risk for cancer, with significant increases in risk for each four-inch increase in height.
Among older women, indoor air pollution associates with increased blood pressure.
Pre-menopausal women with the highest average intakes of folate from the diet are at a 40% reduced risk of developing breast cancer.
Among older women, Vitamin D supplementation extends longevity.
Daily physical activity, a low-fat whole-grain diet, low BMI, and other healthy behaviors significantly reduce a woman’s risk of sudden cardiac death.
Anti-Aging Forum MLDP Join A4M
Post a comment
Write a comment:

Related Searches