Modest glucose control with a hemoglobin A1c between 7.1% and 7.8% showed 27% lower mortality risk than tight control with an A1c of 6.4% or lower (P=0.001), David Aguilar, MD, of Baylor College of Medicine in Houston, and colleagues reported.
This high-risk population had a U-shaped mortality curve, they wrote in the July 28 issue of the Journal of the American College of Cardiology.
Several recent trials have also shown no macrovascular benefit to tight glucose control in general diabetes populations, Dr. Aguilar noted."
More is not always better ! As Gautam Buddha said, sometimes the best path is that of moderation !