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Major Step Towards an Alzheimer’s Vaccine

Posted Jan 24 2013 10:09pm
Posted on Jan. 23, 2013, 6 a.m. in Alzheimer's Disease

The most common cause of dementia worldwide, Alzheimer’s disease (AD) is a neurodegenerative disease that is thought to be associated with the accumulation of amyloid beta. Jean-Philippe Michaud, from Laval University (Canada), and colleagues have identified a molecule that stimulates the activity of the brain's immune cells. The molecule, known as MPL (monophosphoryl lipid A), has been used extensively as a vaccine adjuvant, and with its safety well established.  In mice with Alzheimer's symptoms, weekly injections of MPL over a twelve-week period eliminated up to 80% of senile plaques. In addition, tests measuring the mice's ability to learn new tasks showed significant improvement in cognitive function over the same period.   The researchers see two potential uses for MPL. It could be administered by intramuscular injection to people with Alzheimer's disease to slow the progression of the illness. It could also be incorporated into a vaccine designed to stimulate the production of antibodies against amyloid beta.  The lead investigator submits that: "The vaccine could be given to people who already have the disease to stimulate their natural immunity.  It could also be administered as a preventive measure to people with risk factors for Alzheimer's disease."

Jean-Philippe Michaud, Maxime Halle, Antoine Lampron, Peter Theriault, Paul Prefontaine, Serge Rivest, et al.  “Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology.”  PNAS, January 15, 2013.

  
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#112 - Use In Case of Emergency
The American Red Cross recommends six basics you should stock for your home in the case of an emergency. Keep the items that you would most likely need during an evacuation in an easy-to carry container (a covered trash container, a camping backpack or a duffle bag) that is kept in a readily accessible location (the guest closet or garage, for example).

Your Disaster Supplies Kit should include:
• Water: One gallon of water per person per day, keep at least a three-day supply of water per person.
• Food: A three-day supply of non-perishable food.
• First Aid Supplies: Including bandages, dressings, gloves, anti-bacterials, and non-prescription drugs (pain relievers, antacids, anti-diarrheals, etc); see the web resource below for a more thorough list
• Medications for health conditions
• Clothing
• Bedding
• Tools and emergency supplies
• Special items necessary for infants and elderly or disabled persons
• Copies of key family documents: birth certificates, marriage certificates, passports, drivers licenses, banking and credit card account numbers, insurance policies, health records, household inventory lists; continue reading for further details.
 
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