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Low Vitamin B-6 Linked to Cardiovascular Disease Risk

Posted Jul 30 2012 10:08pm
Posted on July 27, 2012, 6 a.m. in Cardio-Vascular Vitamins

Low levels of vitamin B-6 may contribute to the chronic inflammation involved in cardiovascular disease. Lydia Sakakeeny, from Tufts University (Massachusetts, USA), and colleagues studied 2,289 men and women, average age 61 years, enrolled in the Framingham Offspring Study.  The team analyzed plasma concentrations of pyridoxal-5-phosphate (PLP), a marker of vitamin B-6, and determined an inflammation score for each subject. They found that low levels of pyridoxal-5-phosphate corresponded to a greater overall inflammation score.  Further, the researchers observed that many of the individual inflammatory markers were inversely associated with plasma pyridoxal-5-phosphate, after adjusting for plasma C-reactive protein concentration.  The study authors submit that: "This study, in combination with past findings, further supports our hypothesis that inflammation is associated with a functional deficiency of vitamin B-6.”

Lydia Sakakeeny, Ronenn Roubenoff, Martin Obin, Joao D. Fontes, Emelia J. Benjamin, Yoram Bujanover, et al.  “Plasma Pyridoxal-5-Phosphate Is Inversely Associated with Systemic Markers of Inflammation in a Population of U.S. Adults.” J. Nutr., July 2012 142: 1280-1285.

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15. Delaying Diabetes
New data models derived from the Diabetes Prevention Project by the University of Michigan Health System (USA) show that men and women who walked briskly for 30 minutes five days a week, lowered their fat and calorie intake, and achieved a weight-reduction goal of 7% of body weight over a three-year period were able to cut their risk of developing type 2 diabetes by 58%.
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