Health knowledge made personal
Join this community!
› Share page:
Search posts:

Low Levels of Testosterone May Raise Men’s Diabetes Risk

Posted May 31 2012 10:11pm
Posted on May 31, 2012, 6 a.m. in Diabetes | Men's Health | Testosterone |

Testosterone acts on fat cells through molecules known as androgen receptors, which enable the testosterone to activate genes linked to obesity and diabetes. Kerry McInnes, from the University of Edinburgh (United Kingdom), and colleagues have found mice in which the function of testosterone in fat tissue was impaired were more likely to be insulin resistant than mice in which the role of testosterone was not hindered.  Mice that did not have androgen receptors in fat tissue for testosterone to attach to, were more likely to show signs of insulin resistance than other mice.  The researchers also found that mice without androgen receptors in fat tissue also became fatter than other mice and developed full insulin resistance when both types were fed a high-fat diet.  In that a protein called RBP4 (retinol binding protein 4) is thought to play a crucial role in regulating insulin resistance when testosterone is impaired, the team observed that levels of RBP4 were higher in mice in which the role of testosterone was impaired.

McInnes KJ, Smith LB, Hunger NI, Saunders PT, Andrew R, Walker BR.  “Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis.”  Diabetes. May 2012;61(5):1072-81.

The latest European Guidelines on Cardiovascular Disease Prevention in Clinical Practice recommend that people should eat fish at least twice a week.
Low testosterone levels are found to be linked to a resistance to insulin.
The longer you drive to work, the more likely you are to be overweight and have high blood pressure.
Levels of Insulin-like growth factor (IGF) axis proteins associate with a greatly reduced risk for developing type-2 diabetes up to a decade or more later.
Black pepper is an abundant source of piperine, a compound that Korean researchers report blocks the formation of new fat cells.
People who consume large amounts of omega-3 fatty acids tend to have lower plasma levels of beta-amyloid proteins, a marker of Alzheimer's Disease.
Regular jogging increases the life expectancy of men by 6.2 years and women by 5.6 years.
The United States spends more on health care than 12 other industrialized countries yet does not provide "notably superior" care.
Swedish researchers submit that social, mental, and physical engagement help to preserve cognitive performance in aging.
Danish study data reveals that an increase in BMI of 4 kg/m2 in life increases the risk of developing heart disease by 50%.
Anti-Aging Therapeutics 13   View the Table of Contents
  Order the Book
  Order the eBook Anti-Aging Forum MLDP Anti-aging jobs Join A4M
279. “D”feat the Flu
A growing body of evidence supports a link between Vitamin D and optimal immune health. University School of Medicine (Japan) researchers studied 334 schoolchildren, one group of whom received daily supplements of vitamin D3 (1200 IUs) and the other group received placebo. During the course of four months, the incidence of seasonal influenza was 11% in the Vitamin D supplemented group, as compared to 19% in the placebo group.
Post a comment
Write a comment: