Leptin, Anti-HSP60, Anti-HSP65 and Anti-oxLDL in Autoimmune Rheumatic Diseases
Posted Sep 11 2009 4:56pm
By R. Wu and Colleague
To investigate whether leptin, heat shock proteins (HSP), oxidized low-density lipoprotein (oxLDL) are involved in the autoimmune rheumatic diseases (AIRD). We studied sera of 47 patients with vasculitis, 38 patients with Sjogren’s syndrome (SS), 44 patients with systemic sclerosis (SSc) and 154 sex-matched healthy subjects (HS).
Serum leptin, autoantibody against(anti-) HSP60, HSP65 and oxLDL were determined by EIA. The level of leptin was increased in male patients with vasculitis (p
<0.05), anti-HSP60 in all patient groups was lower (p
<0.05) and anti-oxLDL was higher in SSc-patients (p
<0.05) than HS. We conclude that levels of serum leptin, anti-HSP60, anti-HSP65 and anti-oxLDL multiply varied in vasculitis-patients,SS-patients and SSc-patients. These non-traditional factors are probably involved in the process of AIRD.
By R. Wu and Colleague
To investigate whether leptin, heat shock proteins (HSP), oxidized low-density lipoprotein (oxLDL) are involved in the autoimmune rheumatic diseases (AIRD). We studied sera of 47 patients with vasculitis, 38 patients with Sjogren’s syndrome (SS), 44 patients with systemic sclerosis (SSc) and 154 sex-matched healthy subjects (HS).
Serum leptin, autoantibody against(anti-) HSP60, HSP65 and oxLDL were determined by EIA. The level of leptin was increased in male patients with vasculitis (p <0.05), anti-HSP60 in all patient groups was lower (p <0.05) and anti-oxLDL was higher in SSc-patients (p <0.05) than HS. We conclude that levels of serum leptin, anti-HSP60, anti-HSP65 and anti-oxLDL multiply varied in vasculitis-patients,SS-patients and SSc-patients. These non-traditional factors are probably
involved in the process of AIRD.