Health knowledge made personal
Join this community!
› Share page:
Search posts:

Lack of Melatonin Linked to Amyotrophic Lateral Sclerosis

Posted Jun 13 2013 10:08pm

New research suggests that the sleep hormone melatonin may prove useful in the treatment of the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS). Robert Friedlander, M.D., Professor of neurosurgery and neurobiology at Pitt School of Medicine, and colleagues treated a mouse model of ALS-with injections of melatonin or with a placebo. Results showed that compared to untreated mice, mice treated with melatonin developed symptoms later, survived longer, and had less degeneration of motor neurons in the spinal cord. The study is the first to demonstrate that a lack of melatonin and/or its receptor, melatonin receptor 1 (MT1), is associated with the progression of ALS. The authors concluded that their findings show that melatonin is neuroprotective and that melatonin and modulation of  MT1 pathways “may be promising therapeutic approaches for ALS”.

Yi Zhang, Anna Cook, Jinho Kim, Sergei V. Baranov, Jiying Jiang, Karen Smith, Kerry Cormier, Erik Bennett, Robert P. Browser, Arthur L Day, Diane L Carlisle, Robert J Ferrante, Xin Wang, Robert M Friedlander. Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2013;55C:26-35.

Unwanted gray hair may soon be a thing of the past thanks to a new compound that reverses oxidative stress in the hair follicle.
Switching off a hormone found in fat cells has been shown to improve control of glucose production by the liver.
Eating walnuts or walnut oil can reduce the risk of cardiovascular disease by improving blood vessel function and helping to remove cholesterol from the body.
Increasing the expression of a gene previously linked to Parkinson’s disease has be shown in increase the lifespan of fruit flies by as much as 25%.
Grapes have been found to reduce heart failure associated with chronic high blood pressure.
A study on mice suggests that the hypothalamus may control aging throughout the body.
Research suggests that exercise reduces a woman’s breast cancer risk by increasing the production of “good” estrogen metabolites.
Researchers find that a lack of melatonin is associated with the progression of an animal model of the neurodegenerative disease amyotrophic lateral sclerosis.
Playing a mental agility computer game has been shown to slow cognitive decline in older people.
People taking selective antidepressants around the time of having surgery are found to have an increased risk of bleeding, transfusion, readmission, and death.
Stroke and subclinical markers of vascular disease may be predicative of those older patients with type 2 diabetes who may develop cognitive decline.
Viral and bacterial infections may lead to compromised cognitive skills.
Atrial fibrillation, the most common cardiac arrhythmia, associates with cognitive impairment and dementia, with or without a history of clinical stroke.
Men and women ages 65+ could boost their cognitive function by learning to use Facebook.
Resveratrol, an antioxidant substance found abundantly in red grapes and red wine, may have the potential to protect against hearing loss and cognitive decline.
Higher levels of thrombogenic microvesicles may raise the risk of developing white matter hyperintensities (WMH) in the brain, among postmenopausal women, blood
Older adults may improve their decision making and working memory simply by maintaining a positive mood.
Cardiac disease is an independent risk factor for mild cognitive impairments presaging vascular dementia, among older women.
Dysfunctional pathway may explain the relationship between brain deterioration, sleep disruption and memory loss as we age.
Among older adults, hearing loss associated with accelerated cognitive decline and cognitive impairment.
Anti-Aging Forum MLDP Join A4M
Tip #175 - Circumvent A Cold
Researchers from Carnegie Mellon University (Pennsylvania, USA) studied 153 healthy men and women, ages 21 to 55 years, who reported daily on their sleep duration and quality for two weeks. Participants were then quarantined in separate rooms for 5 days and exposed to rhinovirus (the virus that is responsible for the common cold). As a result, 35.3% of subjects developed a clinical cold and 43.1% self-reported the presence of cold symptoms. The researchers found that those study subjects with shorter duration of sleep and poorer sleep efficiency were at significantly increased risk of developing a cold.

The restorative role of sleep is often underestimated. In that too little sleep has been found to compromise many of the body’s biological processes, including immune function, be sure to achieve sleep of a sufficient duration that is followed by a spontaneous awakening and leaves you feeling refreshed and alert for the day.

Post a comment
Write a comment:

Related Searches