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Ketone Bodies to Protect Tissues from Damage by Ionizing Radiation

Posted Mar 11 2013 8:00pm

Description of Invention:
The invention relates to methods of using ketogenic compounds to protect against the adverse effects of radiation exposure, including ionizing radiation tissue damage. NIH inventors have discovered that ketone esters can be used to reduce tissue damage if administered before or after exposure to radiation. Specifically, the invention relates to esters and oligomers of (R)-3-hydroxybutyrate that are capable of elevating blood levels of (R)-3-hydroxybutyrate and acetoacetate to sufficient levels to reduce cell death caused by radiation-induced damage of DNA and RNA. The development of effective radioprotectant molecules such as these is of great importance in reducing tissue damage following intentional or accidental radiation exposure. This discovery can also increase the therapeutic efficacy of radiation therapies by protecting non-target tissues from incidental radiation damage.

  • Effective therapeutic agent for reducing tissue damage following radiation exposure
  • Protects populations subjected to accidental, incidental, or military exposure to radiation
  • Protects non-target tissue during radiation therapy

  • Can be administered before or after radiation damage
  • Stable at room temperature, allowing easy storage

Development Status:
In vitro data available

Richard L Veech (NIAAA)

Patent Status:
HHS, Reference No. E-258-2012/0
US, Application No. 61/722,630 filed 05 Nov 2012

Collaborative Research Opportunity:
The NIAAA is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize Ketone Bodies to Protect Tissues from Damage by Ionizing Radiation. For collaboration opportunities, please contact Peter B. Silverman, Ph.D., J.D. at or 301-402-6966.

For Licensing Information Please Contact:
Charlene Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4689
Fax: 301-402-0220

Ref No: 2542

Updated: 03/2013

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