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International Study Points To Inflammation As Cause Of Plaque Buildup In Heart Vessels

Posted Dec 02 2012 3:04pm

Fifteen new genetic regions associated with coronary artery disease have been identified by a large, international consortium of scientists — including researchers at the Stanford University School of Medicine — taking a significant step forward in understanding the root causes of this deadly disease. The new research brings the total number of validated genetic links with heart disease discovered through genome-wide association studies to 46.

Coronary artery disease is the process by which plaque builds up in the wall of heart vessels, eventually leading to chest pain and potentially lethal heart attacks. It is the leading cause of death worldwide.

The study, published online Dec. 2 in Nature Genetics, provides insights into the molecular pathways causing coronary artery disease, which is also known as coronary atherosclerosis.

 

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