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Ingredient In Red Wine May Prevent Some Blinding Diseases

Posted Jun 27 2010 2:01pm

On the left, abnormal blood vessels are seen in bright green underneath the mouse retina, but in the image on the right after resveratrol treatment, few abnormal vessels are present.
Resveratrol — found in red wine, grapes, blueberries, peanuts and other plants — stops out-of-control blood vessel growth in the eye, according to vision researchers at Washington University School of Medicine in St. Louis.

The discovery has implications for preserving vision in blinding eye diseases such as diabetic retinopathy and age-related macular degeneration, the leading cause of blindness in Americans over 50.

The formation of new blood vessels, called angiogenesis, also plays a key role in certain cancers and in atherosclerosis. Conducting experiments in mouse retinas, the researchers found that resveratrol can inhibit angiogenesis. Another surprise was the pathway through which resveratrol blocked angiogenesis. The findings are reported in the July issue of the American Journal of Pathology.

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